Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic

Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic

Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects...

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Main Authors: Renato Polimanti, Sara Piacentini, Flavio De Angelis, Gian Franco De Stefano, Maria Fuciarelli
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2011-0821
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spelling doaj-27acf65709b2467e9ca1cce817975d812020-11-24T22:40:41ZengHindawi LimitedDisease Markers0278-02401875-86302011-01-0131423123910.3233/DMA-2011-0821Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental ArsenicRenato Polimanti0Sara Piacentini1Flavio De Angelis2Gian Franco De Stefano3Maria Fuciarelli4Department of Biology, University of Rome “Tor Vergata”, Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Rome, ItalyOver the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demographic history or rather selective pressures.http://dx.doi.org/10.3233/DMA-2011-0821
collection DOAJ
language English
format Article
sources DOAJ
author Renato Polimanti
Sara Piacentini
Flavio De Angelis
Gian Franco De Stefano
Maria Fuciarelli
spellingShingle Renato Polimanti
Sara Piacentini
Flavio De Angelis
Gian Franco De Stefano
Maria Fuciarelli
Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic
Disease Markers
author_facet Renato Polimanti
Sara Piacentini
Flavio De Angelis
Gian Franco De Stefano
Maria Fuciarelli
author_sort Renato Polimanti
title Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic
title_short Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic
title_full Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic
title_fullStr Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic
title_full_unstemmed Human GST Loci as Markers of Evolutionary Forces: GSTO1*E155del and GSTO1*E208K Polymorphisms May Be Under Natural Selection Induced by Environmental Arsenic
title_sort human gst loci as markers of evolutionary forces: gsto1*e155del and gsto1*e208k polymorphisms may be under natural selection induced by environmental arsenic
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2011-01-01
description Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demographic history or rather selective pressures.
url http://dx.doi.org/10.3233/DMA-2011-0821
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