Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge

Eosinophils are important mediators of allergic responses, but how they are recruited to the inflamed site is still unclear. Here the authors show that CD103+ cDC1 cells secrete CCL17 and CCL22 for eosinophil recruitment, with this process promoted by CD24−CD11b+ DC2s in the early phase but suppress...

Full description

Bibliographic Details
Main Authors:	Shuying Yi, Jing Zhai, Rui Niu, Guangming Zhu, Meixiang Wang, Jianguo Liu, Hua Huang, Yaping Wang, Xiuli Jing, Li Kang, Wengang Song, Yufang Shi, Hua Tang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06316-9

id	doaj-27a6b8c71a2d4b0fbb48437037090399
record_format	Article
spelling	doaj-27a6b8c71a2d4b0fbb484370370903992021-05-11T09:51:38ZengNature Publishing GroupNature Communications2041-17232018-09-019111410.1038/s41467-018-06316-9Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challengeShuying Yi0Jing Zhai1Rui Niu2Guangming Zhu3Meixiang Wang4Jianguo Liu5Hua Huang6Yaping Wang7Xiuli Jing8Li Kang9Wengang Song10Yufang Shi11Hua Tang12Institute of Immunology, Taishan Medical UniversitySchool of Basic Medical Sciences, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityShanghai Public Health Clinical Center, Fudan UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Immunology, Taishan Medical UniversityInstitute of Health Sciences, Shanghai Institutes for Biological SciencesInstitute of Immunology, Taishan Medical UniversityEosinophils are important mediators of allergic responses, but how they are recruited to the inflamed site is still unclear. Here the authors show that CD103+ cDC1 cells secrete CCL17 and CCL22 for eosinophil recruitment, with this process promoted by CD24−CD11b+ DC2s in the early phase but suppressed by CD24+ cDC2s in the late phase.https://doi.org/10.1038/s41467-018-06316-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shuying Yi Jing Zhai Rui Niu Guangming Zhu Meixiang Wang Jianguo Liu Hua Huang Yaping Wang Xiuli Jing Li Kang Wengang Song Yufang Shi Hua Tang
spellingShingle	Shuying Yi Jing Zhai Rui Niu Guangming Zhu Meixiang Wang Jianguo Liu Hua Huang Yaping Wang Xiuli Jing Li Kang Wengang Song Yufang Shi Hua Tang Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge Nature Communications
author_facet	Shuying Yi Jing Zhai Rui Niu Guangming Zhu Meixiang Wang Jianguo Liu Hua Huang Yaping Wang Xiuli Jing Li Kang Wengang Song Yufang Shi Hua Tang
author_sort	Shuying Yi
title	Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
title_short	Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
title_full	Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
title_fullStr	Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
title_full_unstemmed	Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
title_sort	eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	Eosinophils are important mediators of allergic responses, but how they are recruited to the inflamed site is still unclear. Here the authors show that CD103+ cDC1 cells secrete CCL17 and CCL22 for eosinophil recruitment, with this process promoted by CD24−CD11b+ DC2s in the early phase but suppressed by CD24+ cDC2s in the late phase.
url	https://doi.org/10.1038/s41467-018-06316-9
work_keys_str_mv	AT shuyingyi eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT jingzhai eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT ruiniu eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT guangmingzhu eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT meixiangwang eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT jianguoliu eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT huahuang eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT yapingwang eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT xiulijing eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT likang eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT wengangsong eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT yufangshi eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge AT huatang eosinophilrecruitmentisdynamicallyregulatedbyinterplayamonglungdendriticcellsubsetsafterallergenchallenge
_version_	1721449028204363776

Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge

Similar Items