Designing Paper-Based Immunoassays for Biomedical Applications

Paper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost...

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Main Authors:	Delyan R. Hristov, Cristina Rodriguez-Quijada, Jose Gomez-Marquez, Kimberly Hamad-Schifferli
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Sensors
Subjects:	paper-based immunoassays lateral flow assay biological sensors dipstick assay rapid diagnostics
Online Access:	https://www.mdpi.com/1424-8220/19/3/554

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record_format	Article
spelling	doaj-27a1bc9fba614a9291fb0861873e90842020-11-24T22:09:56ZengMDPI AGSensors1424-82202019-01-0119355410.3390/s19030554s19030554Designing Paper-Based Immunoassays for Biomedical ApplicationsDelyan R. Hristov0Cristina Rodriguez-Quijada1Jose Gomez-Marquez2Kimberly Hamad-Schifferli3Department of Engineering, University of Massachusetts, Boston, MA 02125, USADepartment of Engineering, University of Massachusetts, Boston, MA 02125, USALittle Devices Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Engineering, University of Massachusetts, Boston, MA 02125, USAPaper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost and simplicity of operation. This review is aimed at examining the fundamentals of the technology, as well as different implementations of paper-based assays and discuss novel strategies for improving their sensitivity, performance, or enabling new capabilities. These innovations can be categorized into using unique nanoparticle materials and structures for detection via different techniques, novel biological species for recognizing biomarkers, or innovative device design and/or architecture.https://www.mdpi.com/1424-8220/19/3/554paper-based immunoassayslateral flow assaybiological sensorsdipstick assayrapid diagnostics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Delyan R. Hristov Cristina Rodriguez-Quijada Jose Gomez-Marquez Kimberly Hamad-Schifferli
spellingShingle	Delyan R. Hristov Cristina Rodriguez-Quijada Jose Gomez-Marquez Kimberly Hamad-Schifferli Designing Paper-Based Immunoassays for Biomedical Applications Sensors paper-based immunoassays lateral flow assay biological sensors dipstick assay rapid diagnostics
author_facet	Delyan R. Hristov Cristina Rodriguez-Quijada Jose Gomez-Marquez Kimberly Hamad-Schifferli
author_sort	Delyan R. Hristov
title	Designing Paper-Based Immunoassays for Biomedical Applications
title_short	Designing Paper-Based Immunoassays for Biomedical Applications
title_full	Designing Paper-Based Immunoassays for Biomedical Applications
title_fullStr	Designing Paper-Based Immunoassays for Biomedical Applications
title_full_unstemmed	Designing Paper-Based Immunoassays for Biomedical Applications
title_sort	designing paper-based immunoassays for biomedical applications
publisher	MDPI AG
series	Sensors
issn	1424-8220
publishDate	2019-01-01
description	Paper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost and simplicity of operation. This review is aimed at examining the fundamentals of the technology, as well as different implementations of paper-based assays and discuss novel strategies for improving their sensitivity, performance, or enabling new capabilities. These innovations can be categorized into using unique nanoparticle materials and structures for detection via different techniques, novel biological species for recognizing biomarkers, or innovative device design and/or architecture.
topic	paper-based immunoassays lateral flow assay biological sensors dipstick assay rapid diagnostics
url	https://www.mdpi.com/1424-8220/19/3/554
work_keys_str_mv	AT delyanrhristov designingpaperbasedimmunoassaysforbiomedicalapplications AT cristinarodriguezquijada designingpaperbasedimmunoassaysforbiomedicalapplications AT josegomezmarquez designingpaperbasedimmunoassaysforbiomedicalapplications AT kimberlyhamadschifferli designingpaperbasedimmunoassaysforbiomedicalapplications
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Designing Paper-Based Immunoassays for Biomedical Applications

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