Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side ch...
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MDPI AG
2014-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/5/2937 |
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doaj-279e565dfd6b441aab300b9e2c4fb0d82020-11-24T21:44:59ZengMDPI AGMarine Drugs1660-33972014-05-011252937295210.3390/md12052937md12052937Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulansChristina Viegelmann0Jennifer Parker1Thengtheng Ooi2Carol Clements3Gráinne Abbott4Louise Young5Jonathan Kennedy6Alan D. W. Dobson7RuAngelie Edrada-Ebel8Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKMarine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, IrelandMarine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, IrelandStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UKThe marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.http://www.mdpi.com/1660-3397/12/5/2937Haliclona simulansmarine spongessteroidsantitrypanosomalanti-mycobacterial |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christina Viegelmann Jennifer Parker Thengtheng Ooi Carol Clements Gráinne Abbott Louise Young Jonathan Kennedy Alan D. W. Dobson RuAngelie Edrada-Ebel |
| spellingShingle |
Christina Viegelmann Jennifer Parker Thengtheng Ooi Carol Clements Gráinne Abbott Louise Young Jonathan Kennedy Alan D. W. Dobson RuAngelie Edrada-Ebel Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans Marine Drugs Haliclona simulans marine sponges steroids antitrypanosomal anti-mycobacterial |
| author_facet |
Christina Viegelmann Jennifer Parker Thengtheng Ooi Carol Clements Gráinne Abbott Louise Young Jonathan Kennedy Alan D. W. Dobson RuAngelie Edrada-Ebel |
| author_sort |
Christina Viegelmann |
| title |
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans |
| title_short |
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans |
| title_full |
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans |
| title_fullStr |
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans |
| title_full_unstemmed |
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans |
| title_sort |
isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2014-05-01 |
| description |
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations. |
| topic |
Haliclona simulans marine sponges steroids antitrypanosomal anti-mycobacterial |
| url |
http://www.mdpi.com/1660-3397/12/5/2937 |
| work_keys_str_mv |
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1725907335185956864 |