Anthraquinone Emodin Inhibits Tumor Necrosis Factor Alpha-Induced Calcification of Human Aortic Valve Interstitial Cells via the NF-κB Pathway

Anthraquinone Emodin Inhibits Tumor Necrosis Factor Alpha-Induced Calcification of Human Aortic Valve Interstitial Cells via the NF-κB Pathway

Exploring effective therapies for delaying calcific heart valve disease (CHVD) is the focus of current cardiovascular clinical and scientific research. In this study, human aortic valve interstitial cells (hVICs) were isolated from patients with CHVD. After expansion, cultured hVICs were induced wit...

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Bibliographic Details
Main Authors: Kang Xu, Tingwen Zhou, Yuming Huang, Qingjia Chi, Jiawei Shi, Peng Zhu, Nianguo Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
calcific aortic valve disease
anthraquinone
NF-κB
bioinformatic analysis
anti-inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01328/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01328/full

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