Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay

Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay

Effects of technical materials of pesticide active ingredients, belonging to various chemical classes, on erythropoiesis in mouse bone marrow were studied as part of the research on the pesticide mutagenic activity in micronucleus test. The purpose of the present study was to estimate the toxic acti...

Full description

Bibliographic Details
Main Authors: Nataliya Ilyushina, Marina Goumenou, Polychronis D. Stivaktakis, Alexander I. Vardavas, Gleb Masaltsev, Nataliya Averianova, Olga Dmitricheva, Yulia Revazova, Aristidis M. Tsatsakis, Valerii Rakitskii
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Toxicology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750018307650
id doaj-27966ea56aa44011bcaae08bf76b4a91
record_format Article
spelling doaj-27966ea56aa44011bcaae08bf76b4a912020-11-25T01:55:53ZengElsevierToxicology Reports2214-75002019-01-016105110Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assayNataliya Ilyushina0Marina Goumenou1Polychronis D. Stivaktakis2Alexander I. Vardavas3Gleb Masaltsev4Nataliya Averianova5Olga Dmitricheva6Yulia Revazova7Aristidis M. Tsatsakis8Valerii Rakitskii9The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast’, 141014, Russian Federation; Corresponding authors.Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, GreeceLaboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, GreeceLaboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, GreeceThe Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast’, 141014, Russian FederationThe Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast’, 141014, Russian FederationThe Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast’, 141014, Russian FederationThe Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast’, 141014, Russian FederationLaboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece; Corresponding authors.The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Oblast’, 141014, Russian FederationEffects of technical materials of pesticide active ingredients, belonging to various chemical classes, on erythropoiesis in mouse bone marrow were studied as part of the research on the pesticide mutagenic activity in micronucleus test. The purpose of the present study was to estimate the toxic action of the test substances on the target organ and the validity of the results of the micronucleus assay under conditions of erythropoiesis suppression.It was demonstrated that intragastrically administrated triazole pesticides reached bone marrow (target organ where micronucleus induction was assessed) and exerted an inhibitory effect on erythropoiesis. The effects of triazole pesticides were enhanced in the following order: difenoconazole ≤ tebuconazole < cyproconazole < flutriafol. Furthermore, an association between structural features of molecules and specific target organ activity of the test pesticides was observed.Based on the data on the general toxicity and the results of the evaluation of the effects on erythropoiesis, the maximum tolerated doses (MTDs) of 79 different technical materials of pesticides for CD-1 mice were determined. Keywords: Pesticides, Triazoles, Maximum tolerated doses, Erythropoiesis, Micronucleus test, Micehttp://www.sciencedirect.com/science/article/pii/S2214750018307650
collection DOAJ
language English
format Article
sources DOAJ
author Nataliya Ilyushina
Marina Goumenou
Polychronis D. Stivaktakis
Alexander I. Vardavas
Gleb Masaltsev
Nataliya Averianova
Olga Dmitricheva
Yulia Revazova
Aristidis M. Tsatsakis
Valerii Rakitskii
spellingShingle Nataliya Ilyushina
Marina Goumenou
Polychronis D. Stivaktakis
Alexander I. Vardavas
Gleb Masaltsev
Nataliya Averianova
Olga Dmitricheva
Yulia Revazova
Aristidis M. Tsatsakis
Valerii Rakitskii
Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
Toxicology Reports
author_facet Nataliya Ilyushina
Marina Goumenou
Polychronis D. Stivaktakis
Alexander I. Vardavas
Gleb Masaltsev
Nataliya Averianova
Olga Dmitricheva
Yulia Revazova
Aristidis M. Tsatsakis
Valerii Rakitskii
author_sort Nataliya Ilyushina
title Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
title_short Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
title_full Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
title_fullStr Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
title_full_unstemmed Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
title_sort maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
publisher Elsevier
series Toxicology Reports
issn 2214-7500
publishDate 2019-01-01
description Effects of technical materials of pesticide active ingredients, belonging to various chemical classes, on erythropoiesis in mouse bone marrow were studied as part of the research on the pesticide mutagenic activity in micronucleus test. The purpose of the present study was to estimate the toxic action of the test substances on the target organ and the validity of the results of the micronucleus assay under conditions of erythropoiesis suppression.It was demonstrated that intragastrically administrated triazole pesticides reached bone marrow (target organ where micronucleus induction was assessed) and exerted an inhibitory effect on erythropoiesis. The effects of triazole pesticides were enhanced in the following order: difenoconazole ≤ tebuconazole < cyproconazole < flutriafol. Furthermore, an association between structural features of molecules and specific target organ activity of the test pesticides was observed.Based on the data on the general toxicity and the results of the evaluation of the effects on erythropoiesis, the maximum tolerated doses (MTDs) of 79 different technical materials of pesticides for CD-1 mice were determined. Keywords: Pesticides, Triazoles, Maximum tolerated doses, Erythropoiesis, Micronucleus test, Mice
url http://www.sciencedirect.com/science/article/pii/S2214750018307650
work_keys_str_mv AT nataliyailyushina maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT marinagoumenou maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT polychronisdstivaktakis maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT alexanderivardavas maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT glebmasaltsev maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT nataliyaaverianova maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT olgadmitricheva maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT yuliarevazova maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT aristidismtsatsakis maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
AT valeriirakitskii maximumtolerateddosesanderythropoiesiseffectsinthemousebonemarrowby79pesticidestechnicalmaterialsassessedwiththemicronucleusassay
_version_ 1724982731791663104

Similar Items