The Emerging Role of Microglia in Neuromyelitis Optica

The Emerging Role of Microglia in Neuromyelitis Optica

Neuromyelitis optica (NMO) is an autoantibody-triggered neuro-inflammatory disease which preferentially attacks the spinal cord and optic nerve. Its defining autoantibody is specific for the water channel protein, aquaporin‐4 (AQP4), which primarily is localized at the end-feet of astrocytes. Histop...

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Bibliographic Details
Main Authors: Tingjun Chen, Dale B. Bosco, Yanlu Ying, Dai-Shi Tian, Long-Jun Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
microglia
neuromyelitis optica
complement C3
aquaporin-4
astrocyte-microglia communication
autoimmune
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.616301/full

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