EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence

EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence

Abstract Background Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials...

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Bibliographic Details
Main Authors: Li Li, Yulun Huang, Yuge Gao, Tengfei Shi, Yunyun Xu, Huini Li, Marko Hyytiäinen, Jorma Keski-Oja, Qiuying Jiang, Yizhou Hu, Zhimin Du
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
Epidermal growth factor
Netrin-4
Glioblastoma
Cell senescence
Online Access:http://link.springer.com/article/10.1186/s12885-018-5056-4

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