Induction therapy in newly diagnosed multiple myeloma: Current research scenario and questions for the future

• Main Authors: Bhausaheb Bagal, Avinash Bonda
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Cancer Research, Statistics, and Treatment
• Subjects: induction therapy; multiple myeloma; outcomes
• Online Access: http://www.crstonline.com/article.asp?issn=2590-3233;year=2019;volume=2;issue=1;spage=76;epage=82;aulast=Bagal

The outcomes of patients with newly diagnosed multiple myeloma (NDMM) have substantially improved over the last decade. Besides improved staging, diagnostic and prognostic tools leading to better risk-stratified approaches, a major contributing factor has been better induction regimens. The major emphasis of the current clinical research is on the development of induction regimens capable of producing a deep and durable remission as measured by minimal residual disease negativity, which correlates with a better overall survival. This review explores the current changing landscape of induction therapy in NDMM and discusses implications for the current clinical practice.