Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure

Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure

Here, we studied the metabolic function of LAMTOR1 from macrophages using LAMTOR1 macrophage-specific knockout (MKO) mice. LAMTOR1 MKO mice showed resistance to high-fat diet (HFD)-induced obesity, lipid steatosis, and glucose metabolic disorders, with elevated levels of pro-inflammatory cytokines....

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Bibliographic Details
Main Authors: Lingwen Ying, Mingliang Zhang, Xiaojing Ma, Yiming Si, Xiaoya Li, Jiaorong Su, Jun Yin, Yuqian Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
late endosomal/lysosomal membrane adaptor p18
Kupffer cell
lipotoxicity
liver steatosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.672032/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.672032/full

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