Binding of the small-molecule kinase inhibitor ruxolitinib to membranes does not disturb membrane integrity

Ruxolitinib is a small-molecule protein kinase inhibitor, which is used as a therapeutic agent against several diseases. Due to its anti-inflammatory impact, ruxolitinib has also been considered recently for usage in the treatment of Covid-19. While the specific effects of ruxolitinib on Janus kinas...

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Bibliographic Details
Main Authors: Markus Fischer, Meike Luck, Maximilian Werle, Holger A. Scheidt, Peter Müller
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
NMR
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820301485