Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

<p>Abstract</p> <p>Background</p> <p>Ergosterol peroxide (EP) derived from edible mushroom has been shown to exert anti-tumor activity in several cancer cells. In the present study, anti-angiogenic activity of EP was investigated with the underlying molecular mechanisms...

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Bibliographic Details
Main Authors: Rhee Yun-Hee, Jeong Soo-Jin, Lee Hyo-Jeong, Lee Hyo-Jung, Koh Wonil, Jung Ji, Kim Sun-Hee, Sung-Hoon Kim
Format: Article
Language:English
Published: BMC 2012-01-01
Series:BMC Cancer
Subjects:
ergosterol peroxide
JAK2
STAT3
angiogenesis
multiple myeloma
Online Access:http://www.biomedcentral.com/1471-2407/12/28

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