From discovery to production: Scale-out of continuous flow meso reactors

From discovery to production: Scale-out of continuous flow meso reactors

A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions ca...

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Bibliographic Details
Main Authors: Peter Styring, Ana I. R. Parracho
Format: Article
Language:English
Published: Beilstein-Institut 2009-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
catalysis
continuous flow
Kumada reaction
parallel
scale-out
Online Access:https://doi.org/10.3762/bjoc.5.29
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spelling doaj-276b32719ef74e6292ddde8f4d240f5f2021-03-02T10:15:32ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972009-06-01512910.3762/bjoc.5.291860-5397-5-29From discovery to production: Scale-out of continuous flow meso reactorsPeter Styring0Ana I. R. Parracho1Department of Chemical & Process Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, United KingdomDepartment of Chemical & Process Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, United KingdomA continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.https://doi.org/10.3762/bjoc.5.29catalysiscontinuous flowKumada reactionparallelscale-out
collection DOAJ
language English
format Article
sources DOAJ
author Peter Styring
Ana I. R. Parracho
spellingShingle Peter Styring
Ana I. R. Parracho
From discovery to production: Scale-out of continuous flow meso reactors
Beilstein Journal of Organic Chemistry
catalysis
continuous flow
Kumada reaction
parallel
scale-out
author_facet Peter Styring
Ana I. R. Parracho
author_sort Peter Styring
title From discovery to production: Scale-out of continuous flow meso reactors
title_short From discovery to production: Scale-out of continuous flow meso reactors
title_full From discovery to production: Scale-out of continuous flow meso reactors
title_fullStr From discovery to production: Scale-out of continuous flow meso reactors
title_full_unstemmed From discovery to production: Scale-out of continuous flow meso reactors
title_sort from discovery to production: scale-out of continuous flow meso reactors
publisher Beilstein-Institut
series Beilstein Journal of Organic Chemistry
issn 1860-5397
publishDate 2009-06-01
description A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.
topic catalysis
continuous flow
Kumada reaction
parallel
scale-out
url https://doi.org/10.3762/bjoc.5.29
work_keys_str_mv AT peterstyring fromdiscoverytoproductionscaleoutofcontinuousflowmesoreactors
AT anairparracho fromdiscoverytoproductionscaleoutofcontinuousflowmesoreactors
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