A positive feedback loop bi-stably activates fibroblasts

A positive feedback loop bi-stably activates fibroblasts

Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C...

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Main Authors: So-Young Yeo, Keun-Woo Lee, Dongkwan Shin, Sugyun An, Kwang-Hyun Cho, Seok-Hyung Kim
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05274-6
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spelling doaj-2764ab54e1634e5dbd32e110b5ef0b152021-05-11T10:05:44ZengNature Publishing GroupNature Communications2041-17232018-08-019111610.1038/s41467-018-05274-6A positive feedback loop bi-stably activates fibroblastsSo-Young Yeo0Keun-Woo Lee1Dongkwan Shin2Sugyun An3Kwang-Hyun Cho4Seok-Hyung Kim5Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityDepartment of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityNormal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C bi-stably.https://doi.org/10.1038/s41467-018-05274-6
collection DOAJ
language English
format Article
sources DOAJ
author So-Young Yeo
Keun-Woo Lee
Dongkwan Shin
Sugyun An
Kwang-Hyun Cho
Seok-Hyung Kim
spellingShingle So-Young Yeo
Keun-Woo Lee
Dongkwan Shin
Sugyun An
Kwang-Hyun Cho
Seok-Hyung Kim
A positive feedback loop bi-stably activates fibroblasts
Nature Communications
author_facet So-Young Yeo
Keun-Woo Lee
Dongkwan Shin
Sugyun An
Kwang-Hyun Cho
Seok-Hyung Kim
author_sort So-Young Yeo
title A positive feedback loop bi-stably activates fibroblasts
title_short A positive feedback loop bi-stably activates fibroblasts
title_full A positive feedback loop bi-stably activates fibroblasts
title_fullStr A positive feedback loop bi-stably activates fibroblasts
title_full_unstemmed A positive feedback loop bi-stably activates fibroblasts
title_sort positive feedback loop bi-stably activates fibroblasts
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C bi-stably.
url https://doi.org/10.1038/s41467-018-05274-6
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