Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/<it>neu </it>single chain Fv for use in ADEPT
<p>Abstract</p> <p>Background</p> <p>Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are immunogenic limiting the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-12-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Online Access: | http://www.jeccr.com/content/28/1/147 |