Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the...

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Bibliographic Details
Main Authors: Daniel Silqueira Martins Guimarães, Amanda Luisa da Fonseca, Ronan Batista, Moacyr Comar Junior, Alaíde Braga de Oliveira, Alex Gutterres Taranto, Fernando de Pilla Varotti
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-04-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
malaria
ent-kaurane diterpenes
PfATP6
docking
computer aided-drug design
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200255&lng=en&tlng=en

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