Pathophysiological and Genetic Aspects of Vascular Calcification
Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic fact...
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2020-01-01
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Series: | Cardiology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2020/5169069 |
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doaj-275e5836dbae4681b743f36b07bd43332020-11-25T02:23:40ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/51690695169069Pathophysiological and Genetic Aspects of Vascular CalcificationLuis Fernando Escobar Guzman0Cristian Andres Escobar Guzman1Neuza Helena Moreira Lopes2Heart Institute (InCor), University of São Paulo Medical School, São Paulo, BrazilDepartment of Pathology, University of São Paulo Medical School, São Paulo, BrazilHeart Institute (InCor), University of São Paulo Medical School, São Paulo, BrazilRecent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Objective. A systematic review of the pathophysiology factors involved in vascular calcification and its genetic influence was performed. Methods. A systematic review was conducted in the Medline and PubMed databases and were searched for studies concerning vascular calcification using the keywords and studies published until 2020/01 in English. Inclusion Criteria. Studies in vitro, animal models, and humans. These include cohort (both retrospective and prospective cohort studies), case-control, cross-sectional, and systematic reviews. Exclusion Criteria. Studies before 2003 of the existing literature.http://dx.doi.org/10.1155/2020/5169069 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luis Fernando Escobar Guzman Cristian Andres Escobar Guzman Neuza Helena Moreira Lopes |
spellingShingle |
Luis Fernando Escobar Guzman Cristian Andres Escobar Guzman Neuza Helena Moreira Lopes Pathophysiological and Genetic Aspects of Vascular Calcification Cardiology Research and Practice |
author_facet |
Luis Fernando Escobar Guzman Cristian Andres Escobar Guzman Neuza Helena Moreira Lopes |
author_sort |
Luis Fernando Escobar Guzman |
title |
Pathophysiological and Genetic Aspects of Vascular Calcification |
title_short |
Pathophysiological and Genetic Aspects of Vascular Calcification |
title_full |
Pathophysiological and Genetic Aspects of Vascular Calcification |
title_fullStr |
Pathophysiological and Genetic Aspects of Vascular Calcification |
title_full_unstemmed |
Pathophysiological and Genetic Aspects of Vascular Calcification |
title_sort |
pathophysiological and genetic aspects of vascular calcification |
publisher |
Hindawi Limited |
series |
Cardiology Research and Practice |
issn |
2090-8016 2090-0597 |
publishDate |
2020-01-01 |
description |
Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Objective. A systematic review of the pathophysiology factors involved in vascular calcification and its genetic influence was performed. Methods. A systematic review was conducted in the Medline and PubMed databases and were searched for studies concerning vascular calcification using the keywords and studies published until 2020/01 in English. Inclusion Criteria. Studies in vitro, animal models, and humans. These include cohort (both retrospective and prospective cohort studies), case-control, cross-sectional, and systematic reviews. Exclusion Criteria. Studies before 2003 of the existing literature. |
url |
http://dx.doi.org/10.1155/2020/5169069 |
work_keys_str_mv |
AT luisfernandoescobarguzman pathophysiologicalandgeneticaspectsofvascularcalcification AT cristianandresescobarguzman pathophysiologicalandgeneticaspectsofvascularcalcification AT neuzahelenamoreiralopes pathophysiologicalandgeneticaspectsofvascularcalcification |
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