Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Abstract Background Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1–6) and are indispensible for brain development and function of the nervous system. However, under neuroinflammatory conditions or brain damage, LPA levels incre...

Full description

Bibliographic Details
Main Authors: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. F. Graier, D. Kratky, E. Malle, W. Sattler
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
Bioactive lipids
LPAR5
PKDs
Signal transduction
Migration
Pro-inflammatory mediators
Online Access:http://link.springer.com/article/10.1186/s12974-017-1024-1

Similar Items

Similar Items