Whole-Body Profiling of Cancer Metastasis with Single-Cell Resolution

Whole-Body Profiling of Cancer Metastasis with Single-Cell Resolution

Stochastic and proliferative events initiated from a single cell can disrupt homeostatic balance and lead to fatal disease processes such as cancer metastasis. To overcome metastasis, it is necessary to detect and quantify sparsely distributed metastatic cells throughout the body at early stages. He...

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Bibliographic Details
Main Authors: Shimpei I. Kubota, Kei Takahashi, Jun Nishida, Yasuyuki Morishita, Shogo Ehata, Kazuki Tainaka, Kohei Miyazono, Hiroki R. Ueda
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
tissue clearing
whole-body profiling
cancer metastasis
CUBIC-cancer analysis
3D cancer atlas
tumor microenvironment
epithelial-mesenchymal transition
pharmacotherapeutic profiling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308069

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