Large-Scale Conformational Transitions and Dimerization Are Encoded in the Amino-Acid Sequences of Hsp70 Chaperones.

Large-Scale Conformational Transitions and Dimerization Are Encoded in the Amino-Acid Sequences of Hsp70 Chaperones.

Hsp70s are a class of ubiquitous and highly conserved molecular chaperones playing a central role in the regulation of proteostasis in the cell. Hsp70s assist a myriad of cellular processes by binding unfolded or misfolded substrates during a complex biochemical cycle involving large-scale structura...

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Bibliographic Details
Main Authors: Duccio Malinverni, Simone Marsili, Alessandro Barducci, Paolo De Los Rios
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4457872?pdf=render

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