Validation of a [3H]Astemizole Binding Assay in HEK293 Cells Expressing HERG K+ Channels

Validation of a [3H]Astemizole Binding Assay in HEK293 Cells Expressing HERG K+ Channels

A radioligand binding assay for the HERG (human ether-a-go-go-related gene) K+ channel was developed to identify compounds which may have inhibitory activity and potential cardiotoxicity. Pharmacological characterization of the [3H]astemizole binding assay for HERG K+ channels was performed using HE...

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Bibliographic Details
Main Authors: Peter J.S. Chiu, Karen F. Marcoe, Sidney E. Bounds, Chun-Hsiung Lin, Jin-Jye Feng, Atsui Lin, Fong-Chi Cheng, William J. Crumb, Richard Mitchell
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319324107

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