Recent Advances in Allergy Research Using Humanized Mice

The prevalence rates of allergic diseases are increasing worldwide, particularly in industrial countries. To date, many mouse models have been generated for allergy research; studies conducted using these models have suggested the importance of cross-talk between immune cells and tissue-resident non...

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Main Authors:	Ryoji Ito, Shuichiro Maruoka, Yasuhiro Gon, Ikumi Katano, Takeshi Takahashi, Mamoru Ito, Kenji Izuhara, Satoshi Nunomura
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	International Journal of Molecular Sciences
Subjects:	airway inflammation allergy disease model eosinophil humanized mouse
Online Access:	https://www.mdpi.com/1422-0067/20/11/2740

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spelling	doaj-2744afb070b54e258ace686f787a5a982020-11-24T21:20:18ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-06-012011274010.3390/ijms20112740ijms20112740Recent Advances in Allergy Research Using Humanized MiceRyoji Ito0Shuichiro Maruoka1Yasuhiro Gon2Ikumi Katano3Takeshi Takahashi4Mamoru Ito5Kenji Izuhara6Satoshi Nunomura7Central Institute for Experimental Animals (CIEA), Kawasaki 210-0821, JapanDivision of Respiratory Medicine, Nihon University School of Medicine, Tokyo 173-8610, JapanDivision of Respiratory Medicine, Nihon University School of Medicine, Tokyo 173-8610, JapanCentral Institute for Experimental Animals (CIEA), Kawasaki 210-0821, JapanCentral Institute for Experimental Animals (CIEA), Kawasaki 210-0821, JapanCentral Institute for Experimental Animals (CIEA), Kawasaki 210-0821, JapanDivision of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga 849-0937, JapanDivision of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga 849-0937, JapanThe prevalence rates of allergic diseases are increasing worldwide, particularly in industrial countries. To date, many mouse models have been generated for allergy research; studies conducted using these models have suggested the importance of cross-talk between immune cells and tissue-resident non-immune cells in the onset of allergic diseases. However, there are several differences between the immune systems of rodents and humans, and human studies are limited. Thus, mice reconstituted with human immune cells are a novel tool for the preclinical evaluation of the efficacy and safety of developing drugs. Genetic technologies for generating humanized mice have improved markedly in recent years. In this review, we will discuss recent progress in allergy research using humanized mice and introduce our recent humanized mouse model of airway inflammation in human immune cells.https://www.mdpi.com/1422-0067/20/11/2740airway inflammationallergydisease modeleosinophilhumanized mouse
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ryoji Ito Shuichiro Maruoka Yasuhiro Gon Ikumi Katano Takeshi Takahashi Mamoru Ito Kenji Izuhara Satoshi Nunomura
spellingShingle	Ryoji Ito Shuichiro Maruoka Yasuhiro Gon Ikumi Katano Takeshi Takahashi Mamoru Ito Kenji Izuhara Satoshi Nunomura Recent Advances in Allergy Research Using Humanized Mice International Journal of Molecular Sciences airway inflammation allergy disease model eosinophil humanized mouse
author_facet	Ryoji Ito Shuichiro Maruoka Yasuhiro Gon Ikumi Katano Takeshi Takahashi Mamoru Ito Kenji Izuhara Satoshi Nunomura
author_sort	Ryoji Ito
title	Recent Advances in Allergy Research Using Humanized Mice
title_short	Recent Advances in Allergy Research Using Humanized Mice
title_full	Recent Advances in Allergy Research Using Humanized Mice
title_fullStr	Recent Advances in Allergy Research Using Humanized Mice
title_full_unstemmed	Recent Advances in Allergy Research Using Humanized Mice
title_sort	recent advances in allergy research using humanized mice
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2019-06-01
description	The prevalence rates of allergic diseases are increasing worldwide, particularly in industrial countries. To date, many mouse models have been generated for allergy research; studies conducted using these models have suggested the importance of cross-talk between immune cells and tissue-resident non-immune cells in the onset of allergic diseases. However, there are several differences between the immune systems of rodents and humans, and human studies are limited. Thus, mice reconstituted with human immune cells are a novel tool for the preclinical evaluation of the efficacy and safety of developing drugs. Genetic technologies for generating humanized mice have improved markedly in recent years. In this review, we will discuss recent progress in allergy research using humanized mice and introduce our recent humanized mouse model of airway inflammation in human immune cells.
topic	airway inflammation allergy disease model eosinophil humanized mouse
url	https://www.mdpi.com/1422-0067/20/11/2740
work_keys_str_mv	AT ryojiito recentadvancesinallergyresearchusinghumanizedmice AT shuichiromaruoka recentadvancesinallergyresearchusinghumanizedmice AT yasuhirogon recentadvancesinallergyresearchusinghumanizedmice AT ikumikatano recentadvancesinallergyresearchusinghumanizedmice AT takeshitakahashi recentadvancesinallergyresearchusinghumanizedmice AT mamoruito recentadvancesinallergyresearchusinghumanizedmice AT kenjiizuhara recentadvancesinallergyresearchusinghumanizedmice AT satoshinunomura recentadvancesinallergyresearchusinghumanizedmice
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Recent Advances in Allergy Research Using Humanized Mice

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