BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors

BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors

Brain-derived neurotrophic factor (BDNF) is a key regulator of neuronal plasticity and cognitive functions. BDNF val66met polymorphism, a human single-nucleotide polymorphism (SNP) in the pro-domain of BDNF gene, is associated with deficits in activity-dependent BDNF secretion and hippocampus-depend...

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Bibliographic Details
Main Authors: Rui Hao, Yu Qi, Dong-Ni Hou, Yuan-Yuan Ji, Chun-Yan Zheng, Chu-Yu Li, Wing-Ho Yung, Bai Lu, Ying Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
BDNF val66met polymorphism
5-HT3 receptors
LTD
hippocampus
synaptic plasticity
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00306/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00306/full

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