A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regu...
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Bibliographic Details
| Main Authors: |
Xuexin Zhang,
Trayambak Pathak,
Ryan Yoast,
Scott Emrich,
Ping Xin,
Robert M. Nwokonko,
Martin Johnson,
Shilan Wu,
Céline Delierneux,
Maxime Gueguinou,
Nadine Hempel,
James W. Putney,
Donald L. Gill,
Mohamed Trebak |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-09593-0
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