A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV, Nairoviridae) exhibits extensive genomic sequence diversi...

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Bibliographic Details
Main Authors: Brian L Hua, Florine EM Scholte, Valerie Ohlendorf, Anne Kopp, Marco Marklewitz, Christian Drosten, Stuart T Nichol, Christina Spiropoulou, Sandra Junglen, Éric Bergeron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
congo hemorrhagic fever virus
nairoviridae
tick-borne virus
virus pathogenesis
membrane fusion
phylogenetic
Online Access:https://elifesciences.org/articles/50999

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