Incidence of Pregnancy-Associated Cancer in Two Canadian Provinces: A Population-Based Study

• Main Authors: Amy Metcalfe, Zoe F. Cairncross, Christine M. Friedenreich, Joel G. Ray, Gregg Nelson, Deshayne B. Fell, Sarka Lisonkova, Parveen Bhatti, Carly McMorris, Khokan C. Sikdar, Lorraine Shack
• Format: Article
• Language: English
• Published: MDPI AG 2021-03-01
• Series: International Journal of Environmental Research and Public Health
• Subjects: cancer incidence rate; pregnancy-associated cancer; temporal trends; epidemiology; pregnancy; obstetrics
• Online Access: https://www.mdpi.com/1660-4601/18/6/3100

Pregnancy-associated cancer—that is diagnosed in pregnancy or within 365 days after delivery—is increasingly common as cancer therapy evolves and survivorship increases. This study assessed the incidence and temporal trends of pregnancy-associated cancer in Alberta and Ontario—together accounting for 50% of Canada’s entire population. Linked data from the two provincial cancer registries and health administrative data were used to ascertain new diagnoses of cancer, livebirths, stillbirths and induced abortions among women aged 18–50 years, from 2003 to 2015. The annual crude incidence rate (IR) was calculated as the number of women with a pregnancy-associated cancer per 100,000 deliveries. A nonparametric test for trend assessed for any temporal trends. In Alberta, the crude IR of pregnancy-associated cancer was 156.2 per 100,000 deliveries (95% CI 145.8–166.7), and in Ontario, the IR was 149.4 per 100,000 deliveries (95% CI 143.3–155.4). While no statistically significant temporal trend in the IR of pregnancy-associated cancer was seen in Alberta, there was a rise in Ontario (<i>p</i> = 0.01). Pregnancy-associated cancer is common enough to warrant more detailed research on maternal, pregnancy and child outcomes, especially as cancer therapies continue to evolve.