Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease

Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and activation of the innate and adaptive immune systems. Disruption of immune signaling between...

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Bibliographic Details
Main Authors: Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Aaron D. Thome, David G. Standaert, Ashley S. Harms
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease (PD)
Class II transactivator (CIITA)
α-Synuclein
Major histocompatibility complex II (MHCII)
Neuroinflammation
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s12974-018-1286-2

Internet

http://link.springer.com/article/10.1186/s12974-018-1286-2

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