Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells

Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells

Abstract Background The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hypoxia and inflammation in arthritis, and this inflammatory response is m...

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Bibliographic Details
Main Authors: Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W. N. Ueng, Chuen-Yung Yang, Tsung-Ting Tsai, Po-Liang Lai
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Arthritis Research & Therapy
Subjects:
Hyperbaric oxygen
Nucleus pulposus cells
miR-107
HMGB1
RAGE
Online Access:http://link.springer.com/article/10.1186/s13075-019-1830-1

Internet

http://link.springer.com/article/10.1186/s13075-019-1830-1

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