Rapid Assessment of Functional Avidity of Tumor-Specific T Cell Receptors Using an Antigen-Presenting Tumor Cell Line Electroporated with Full-Length Tumor Antigen mRNA

Rapid Assessment of Functional Avidity of Tumor-Specific T Cell Receptors Using an Antigen-Presenting Tumor Cell Line Electroporated with Full-Length Tumor Antigen mRNA

The functional avidity of T-cell receptor (TCR)-engineered T cells towards their cognate epitope plays a crucial role in successfully targeting and killing tumor cells expressing the tumor-associated antigen (TAA). When evaluating in vitro functional T-cell avidity, an important aspect that is often...

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Bibliographic Details
Main Authors: Diana Campillo-Davo, Maarten Versteven, Gils Roex, Hans De Reu, Sanne van der Heijden, Sébastien Anguille, Zwi N. Berneman, Viggo F. I. Van Tendeloo, Eva Lion
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
model antigen-presenting cell
t-cell functional avidity
full-length antigen mrna electroporation
wilms’ tumor 1
cancer immunotherapy
Online Access:https://www.mdpi.com/2072-6694/12/2/256

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