Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease

<p>Abstract</p> <p>Background</p> <p>Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.</p> <...

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Main Authors: Sanz Yolanda, Calabuig Miguel, Donat Ester, Ribes-Koninckx Carmen, Collado Maria
Format: Article
Language:English
Published: BMC 2008-12-01
Series:BMC Microbiology
Online Access:http://www.biomedcentral.com/1471-2180/8/232
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spelling doaj-271a396fce5745988ddd0495d4a1002c2020-11-25T01:06:01ZengBMCBMC Microbiology1471-21802008-12-018123210.1186/1471-2180-8-232Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac diseaseSanz YolandaCalabuig MiguelDonat EsterRibes-Koninckx CarmenCollado Maria<p>Abstract</p> <p>Background</p> <p>Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.</p> <p>A total of 48 faecal samples (30 and 18 samples from active and no active CD patients, respectively) and 33 duodenal biopsy specimens of CD patients (25 and 8 samples from active and non-active CD patients, respectively) were analysed. Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut <it>Bifidobacterium </it>genus and species were analyzed by real-time PCR.</p> <p>Results</p> <p>Active and non-active CD patients showed lower numbers of total <it>Bifidobacterium </it>and <it>B. longum </it>species in faeces and duodenal biopsies than controls, and these differences were particularly remarkable between active CD patients and controls. <it>B. catenulatum </it>prevalence was higher in biopsies of controls than in those of active and non-active CD patients, whereas <it>B. dentium </it>prevalence was higher in faeces of non-active CD patients than in controls. Correlations between levels of <it>Bifidobacterium </it>and <it>B. longum </it>species in faecal and biopsy samples were detected in both CD patients and controls.</p> <p>Conclusion</p> <p>Reductions in total <it>Bifidobacterium </it>and <it>B. longum </it>populations were associated with both active and non-active CD when compared to controls. These bacterial groups could constitute novel targets for adjuvant dietary therapies although the confirmation of this hypothesis would require further investigations.</p> http://www.biomedcentral.com/1471-2180/8/232
collection DOAJ
language English
format Article
sources DOAJ
author Sanz Yolanda
Calabuig Miguel
Donat Ester
Ribes-Koninckx Carmen
Collado Maria
spellingShingle Sanz Yolanda
Calabuig Miguel
Donat Ester
Ribes-Koninckx Carmen
Collado Maria
Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
BMC Microbiology
author_facet Sanz Yolanda
Calabuig Miguel
Donat Ester
Ribes-Koninckx Carmen
Collado Maria
author_sort Sanz Yolanda
title Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
title_short Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
title_full Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
title_fullStr Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
title_full_unstemmed Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
title_sort imbalances in faecal and duodenal <it>bifidobacterium </it>species composition in active and non-active coeliac disease
publisher BMC
series BMC Microbiology
issn 1471-2180
publishDate 2008-12-01
description <p>Abstract</p> <p>Background</p> <p>Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.</p> <p>A total of 48 faecal samples (30 and 18 samples from active and no active CD patients, respectively) and 33 duodenal biopsy specimens of CD patients (25 and 8 samples from active and non-active CD patients, respectively) were analysed. Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut <it>Bifidobacterium </it>genus and species were analyzed by real-time PCR.</p> <p>Results</p> <p>Active and non-active CD patients showed lower numbers of total <it>Bifidobacterium </it>and <it>B. longum </it>species in faeces and duodenal biopsies than controls, and these differences were particularly remarkable between active CD patients and controls. <it>B. catenulatum </it>prevalence was higher in biopsies of controls than in those of active and non-active CD patients, whereas <it>B. dentium </it>prevalence was higher in faeces of non-active CD patients than in controls. Correlations between levels of <it>Bifidobacterium </it>and <it>B. longum </it>species in faecal and biopsy samples were detected in both CD patients and controls.</p> <p>Conclusion</p> <p>Reductions in total <it>Bifidobacterium </it>and <it>B. longum </it>populations were associated with both active and non-active CD when compared to controls. These bacterial groups could constitute novel targets for adjuvant dietary therapies although the confirmation of this hypothesis would require further investigations.</p>
url http://www.biomedcentral.com/1471-2180/8/232
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