Benzydamine Reverses TMexCD-TOprJ-Mediated High-Level Tigecycline Resistance in Gram-Negative Bacteria

Benzydamine Reverses TMexCD-TOprJ-Mediated High-Level Tigecycline Resistance in Gram-Negative Bacteria

Recently, a novel efflux pump gene cluster called <i>tmexCD1-toprJ1</i> and its variants have been identified, which undermine the antibacterial activity of tigecycline, one of the last remaining options effective against multidrug-resistant (MDR) Gram-negative bacteria. Herein, we repor...

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Bibliographic Details
Main Authors: Ziwen Tong, Tianqi Xu, Tian Deng, Jingru Shi, Zhiqiang Wang, Yuan Liu
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
tigecycline resistance
efflux pump
<i>tmexCD-toprJ</i>
benzydamine
Gram-negative bacteria
Online Access:https://www.mdpi.com/1424-8247/14/9/907

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