Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient

Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient

Acute renal failure can be caused by calcineurin inhibitors (CNIs), due to arteriolopathy and altered tubular function. Within this context, we present the case of a 14-month-old liver transplant recipient who suffered an acute polyuric renal failure during a short episode of hypercaloric feeding. I...

Full description

Bibliographic Details
Main Authors: R. Kula, M. Melter, J. Kunkel, C. Dörfler, S. Alikadic, B. Knoppke, R. Zant
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Transplantation
Online Access:http://dx.doi.org/10.1155/2017/7345680
id doaj-2717f5ceb47546afac3ee29c1ebca942
record_format Article
spelling doaj-2717f5ceb47546afac3ee29c1ebca9422020-11-24T23:55:14ZengHindawi LimitedCase Reports in Transplantation2090-69432090-69512017-01-01201710.1155/2017/73456807345680Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant RecipientR. Kula0M. Melter1J. Kunkel2C. Dörfler3S. Alikadic4B. Knoppke5R. Zant6KUNO University Children’s Hospital, Regensburg, GermanyKUNO University Children’s Hospital, Regensburg, GermanyKUNO University Children’s Hospital, Regensburg, GermanyKUNO University Children’s Hospital, Regensburg, GermanyKUNO University Children’s Hospital, Regensburg, GermanyKUNO University Children’s Hospital, Regensburg, GermanyKUNO University Children’s Hospital, Regensburg, GermanyAcute renal failure can be caused by calcineurin inhibitors (CNIs), due to arteriolopathy and altered tubular function. Within this context, we present the case of a 14-month-old liver transplant recipient who suffered an acute polyuric renal failure during a short episode of hypercaloric feeding. In our case, CNI-induced distal RTA led to nephrocalcinosis and therefore to secondary nephrogenic diabetes insipidus. The diet with high renal solute load consequently resulted in an acute polyuric renal failure with severe hypernatremic dehydration. In conclusion, a hypercaloric diet in children with potentially impaired renal function due to therapy with CNIs requires precise calculation of the potential renal solute load and the associated fluid requirements.http://dx.doi.org/10.1155/2017/7345680
collection DOAJ
language English
format Article
sources DOAJ
author R. Kula
M. Melter
J. Kunkel
C. Dörfler
S. Alikadic
B. Knoppke
R. Zant
spellingShingle R. Kula
M. Melter
J. Kunkel
C. Dörfler
S. Alikadic
B. Knoppke
R. Zant
Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient
Case Reports in Transplantation
author_facet R. Kula
M. Melter
J. Kunkel
C. Dörfler
S. Alikadic
B. Knoppke
R. Zant
author_sort R. Kula
title Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient
title_short Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient
title_full Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient
title_fullStr Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient
title_full_unstemmed Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient
title_sort tacrolimus aggravated tube feeding syndrome with acute renal failure in a pediatric liver transplant recipient
publisher Hindawi Limited
series Case Reports in Transplantation
issn 2090-6943
2090-6951
publishDate 2017-01-01
description Acute renal failure can be caused by calcineurin inhibitors (CNIs), due to arteriolopathy and altered tubular function. Within this context, we present the case of a 14-month-old liver transplant recipient who suffered an acute polyuric renal failure during a short episode of hypercaloric feeding. In our case, CNI-induced distal RTA led to nephrocalcinosis and therefore to secondary nephrogenic diabetes insipidus. The diet with high renal solute load consequently resulted in an acute polyuric renal failure with severe hypernatremic dehydration. In conclusion, a hypercaloric diet in children with potentially impaired renal function due to therapy with CNIs requires precise calculation of the potential renal solute load and the associated fluid requirements.
url http://dx.doi.org/10.1155/2017/7345680
work_keys_str_mv AT rkula tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
AT mmelter tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
AT jkunkel tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
AT cdorfler tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
AT salikadic tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
AT bknoppke tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
AT rzant tacrolimusaggravatedtubefeedingsyndromewithacuterenalfailureinapediatriclivertransplantrecipient
_version_ 1725463483681603584

Similar Items