Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

The low-density lipoprotein receptor (LDLR) is the first described receptor for apolipoprotein E (apoE). We hypothesize that the absence of the LDLR, similar to the absence of apoE, results in impaired learning and memory processes. Six-month-old homozygous Ldlr−/− and wild-type littermates (Ldlr+/+...

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Bibliographic Details
Main Authors: Monique Mulder, Paula J Jansen, Ben J.A Janssen, Wilma D.J van de Berg, Hans van der Boom, Louis M Havekes, Ron E de Kloet, Frans C.S Ramaekers, Arjan Blokland
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Neurobiology of Disease
Subjects:
Apolipoprotein E
Alzheimer's disease
Lipid metabolism
Low-density lipoprotein receptor family
Memory
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000233

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