Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

Abnormal elevation of amyloid β-peptide (Aβ) levels in the brain is the primary trigger for neuronal cell death specific to Alzheimer’s disease (AD). It is now evident that Aβ levels in the brain are manipulable due to a dynamic equilibrium between its production from the amyloid precursor protein (...

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Bibliographic Details
Main Authors: Natalia N Nalivaeva, Nikolai D Belyaev, Caroline eKerridge, Anthony J Turner
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Histone Deacetylases
Neprilysin
APP
AICD
transthyretin
Endothelin-converting enzyme
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00235/full

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