Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dos...

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Bibliographic Details
Main Authors: Weiqian Chen, Peng Zou, Zhongwei Zhao, Xi Chen, Xiaoxi Fan, Rajamanickam Vinothkumar, Ri Cui, Fazong Wu, Qianqian Zhang, Guang Liang, Jiansong Ji
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Redox Biology
Subjects:
Gastric cancer
Rapamycin
EF24
Oxidative stress
Cytotoxicity
Antitumor
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716301331

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