Effect of Oestradiol Administration on Rat Submandibular Gland after Ovariectomized Period

• Main Authors: Berna Güney Saruhan, M. Aydın Ketani
• Format: Article
• Language: English
• Published: Dicle University Medical School 2004-01-01
• Series: Dicle Medical Journal
• Subjects: Menopause; Sex Hormones; Salivary Glands
• Online Access: http://4181.indexcopernicus.com/fulltxt.php?ICID=887956

In this study, we aimed to investigate exogen estrogen on submandibulargland of adult ovariectomized rats. To this end, thirty-six virgin female WistarAlbino rats were used and were divided into three equal groups. Sham groupsreceived no treatment, all animals in the other two groups were bilaterallyovariectomized. Control groups was designated bilaterally ovariectomized andoestradiol was given application groups.Following the applications all animals were sacrified,then submandibulargland was excised and paraffin wax. Paraffin sections, obtained by routinehistologic methods, were cut at 5μm and stained with Hematoxilen-Eozin. Thestained sections were later evaluated under a light microscopy.Histological studies indicated that, after oestrogen deficiency period, theglandular parenchyma and stroma was destroyed. When oestrogen was givenexogenously, it was seen that after ovariectomy, the gland was partially improved.These data demonstrate that oestrogen deficiency play a role in rat of thesubmandibular gland. Exogenous oestrogen leads to partial improvement andoestrogen deficiency doesnt lead to changes of the gland. Exogenous oestrogendoes not completely prevent submandibular gland structure