Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.

Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the etiological agent of Buruli ulcer. Its involvement in lesion development has been widely described in early stages of the disease, through its cytotoxic and immunosuppressive activities, but less is known a...

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Main Authors: M Foulon, M Robbe-Saule, J Manry, L Esnault, Y Boucaud, A Alcaïs, M Malloci, M Fanton d'Andon, T Beauvais, N Labarriere, P Jeannin, L Abel, J P Saint-André, A Croué, Y Delneste, I G Boneca, L Marsollier, E Marion
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009107

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