Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans

Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans

The folate biosynthetic pathway is a promising and understudied source for novel antifungals. Even dihydrofolate reductase (DHFR), a well-characterized and historically important drug target, has not been conclusively validated as an antifungal target. Here, we demonstrate that repression of DHFR in...

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Bibliographic Details
Main Authors: Christian DeJarnette, Arturo Luna-Tapia, Leanna R. Estredge, Glen E. Palmer
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSphere
Subjects:
candida albicans
antifungal agents
dihydrofolate reductase
Online Access:https://doi.org/10.1128/mSphere.00374-20

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