High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke

High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke

Abstract Background A high-salt diet (HSD) is one of the major risk factors for acute ischemic stroke (AIS). As a potential mechanism, surplus salt intake primes macrophages towards a proinflammatory phenotype. In this study, whether HSD could blunt the efferocytic capability of macrophages after is...

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Bibliographic Details
Main Authors: Mengyan Hu, Yinyao Lin, Xuejiao Men, Shisi Wang, Xiaobo Sun, Qiang Zhu, Danli Lu, Sanxin Liu, Bingjun Zhang, Wei Cai, Zhengqi Lu
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
High-salt diet
Stroke
Macrophage
Phagocytosis
Triggering receptor expressed on myeloid cells 2
Online Access:https://doi.org/10.1186/s12974-021-02144-9

Internet

https://doi.org/10.1186/s12974-021-02144-9

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