DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection

DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection

DExD/H-box helicase 36 (DHX36) is known to be an ATP-dependent RNA helicase that unwinds the guanine-quadruplexes DNA or RNA, but emerging data suggest that it also functions as pattern recognition receptor in innate immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arteriv...

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Bibliographic Details
Main Authors: Huiyuan Jing, Yanrong Zhou, Liurong Fang, Zhen Ding, Dang Wang, Wenting Ke, Huanchun Chen, Shaobo Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
porcine reproductive and respiratory syndrome virus
DExD/H-box helicase 36
nucleocapsid protein
NF-κB
pro-inflammatory cytokine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01365/full

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