Circulating T cell subsets are associated with clinical outcome of anti-VEGF-based 1st-line treatment of metastatic colorectal cancer patients: a prospective study with focus on primary tumor sidedness

Circulating T cell subsets are associated with clinical outcome of anti-VEGF-based 1st-line treatment of metastatic colorectal cancer patients: a prospective study with focus on primary tumor sidedness

Abstract Background In a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical outcome. Our primary goal was to investigate whether baseline levels o...

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Bibliographic Details
Main Authors: Beatrix Bencsikova, Eva Budinska, Iveta Selingerova, Katerina Pilatova, Lenka Fedorova, Kristina Greplova, Rudolf Nenutil, Dalibor Valik, Radka Obermannova, Michael A. Sheard, Lenka Zdrazilova-Dubska
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
Metastatic colorectal cancer
T cell subsets
Regulatory T cells
Antitumor immune response
Anti-VEGF
Primary colorectal carcinoma sidedness
Online Access:http://link.springer.com/article/10.1186/s12885-019-5909-5

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