FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c

FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c

Abstract Background Excessive intrahepatic lipid accumulation is the major characteristic of nonalcoholic fatty liver disease (NAFLD). We sought to identify the mechanisms involved in hepatic triglyceride (TG) homeostasis. Forkhead box class O (FoxO) transcription factors have been shown to play an...

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Bibliographic Details
Main Authors: Liu Wang, Xiaopeng Zhu, Xiaoyang Sun, Xinyu Yang, Xinxia Chang, Mingfeng Xia, Yan Lu, Pu Xia, Hongmei Yan, Hua Bian, Xin Gao
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Lipids in Health and Disease
Subjects:
Nonalcoholic fatty liver disease
NAFLD
Forkhead box class O3
FoxO3
Sterol regulatory element-binding protein1c
SREBP1c
Online Access:http://link.springer.com/article/10.1186/s12944-019-1132-2

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