All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity

All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity

The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread despite the global efforts taken to control it. The 3C-like protease (3CLpro), the major protease of SARS-CoV-2, is one of the most interesting targets for antiviral drug development because it is highly conserved among SARS-CoVs and...

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Bibliographic Details
Main Authors: Takeshi Morita, Kei Miyakawa, Sundararaj Stanleyraj Jeremiah, Yutaro Yamaoka, Mitsuru Sada, Tomoko Kuniyoshi, Jinwei Yang, Hirokazu Kimura, Akihide Ryo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
3CL protease
high throughput screening
all-trans retinoic acid
FDA-approved drug
antiviral efficacy
SARS-CoV-2
Online Access:https://www.mdpi.com/1999-4915/13/8/1669

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