Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase

Thiolases are a well characterized family of enzymes with two distinct categories: degradative, β-ketoadipyl-CoA thiolases and biosynthetic, acetoacetyl-CoA thiolases. Both classes share an identical catalytic triad but catalyze reactions in opposite directions. Moreover, it is established that in c...

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Bibliographic Details
Main Authors: Sukritee Bhaskar, David L. Steer, Ruchi Anand, Santosh Panjikar
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Structural Biology: X
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152419300169