Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.

Niemann-Pick type C (NPC) disease is a genetically inherited multi-lipid storage disorder with impaired efflux of cholesterol from lysosomal storage organelles.The effect of screen-selected cholesterol lowering compounds on the major sterol pathways was studied in CT60 mutant CHO cells lacking NPC1...

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Bibliographic Details
Main Authors: Madalina Rujoi, Nina H Pipalia, Frederick R Maxfield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2943465?pdf=render

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