Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin

Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin

<p>Abstract</p> <p>Background</p> <p>Apoptosis resistance occurs in various tumors. The anti-apoptotic XIAP protein is responsible for inhibiting apoptosis by reducing caspase-3 activation. Our aim is to evaluate whether RNA inhibition against XIAP increases the sensiti...

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Bibliographic Details
Main Authors: Rothuizen Jan, Rutteman Gerard R, Arends Brigitte, Jonkers Martijn DB, Spee Bart, Penning Louis C
Format: Article
Language:English
Published: BMC 2006-09-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/5/1/34

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