Early-life social experience affects offspring DNA methylation and later life stress phenotype
Early social experience can alter epigenetic patterns and stress responses later in life. A study on wild spotted hyenas finds that maternal care and social connections after leaving the den influence DNA methylation and contribute to a developmentally plastic stress response.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24583-x |
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doaj-26a7708842bf456a9e9e486a8e5289da |
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doaj-26a7708842bf456a9e9e486a8e5289da2021-07-25T11:39:10ZengNature Publishing GroupNature Communications2041-17232021-07-0112111510.1038/s41467-021-24583-xEarly-life social experience affects offspring DNA methylation and later life stress phenotypeZachary M. Laubach0Julia R. Greenberg1Julie W. Turner2Tracy M. Montgomery3Malit O. Pioon4Maggie A. Sawdy5Laura Smale6Raymond G. Cavalcante7Karthik R. Padmanabhan8Claudia Lalancette9Bridgett vonHoldt10Christopher D. Faulk11Dana C. Dolinoy12Kay E. Holekamp13Wei Perng14Department of Integrative Biology, Michigan State UniversityDepartment of Integrative Biology, Michigan State UniversityDepartment of Integrative Biology, Michigan State UniversityDepartment of Integrative Biology, Michigan State UniversityMara Hyena Project, Masai Mara National ReserveDepartment of Integrative Biology, Michigan State UniversityDepartment of Integrative Biology, Michigan State UniversityEpigenomics Core, University of MichiganEpigenomics Core, University of MichiganEpigenomics Core, University of MichiganDepartment of Ecology and Evolutionary Biology, Princeton UniversityDepartment of Animal Sciences, University of MinnesotaEpigenomics Core, University of MichiganDepartment of Integrative Biology, Michigan State UniversityDepartment of Epidemiology and Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado DenverEarly social experience can alter epigenetic patterns and stress responses later in life. A study on wild spotted hyenas finds that maternal care and social connections after leaving the den influence DNA methylation and contribute to a developmentally plastic stress response.https://doi.org/10.1038/s41467-021-24583-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zachary M. Laubach Julia R. Greenberg Julie W. Turner Tracy M. Montgomery Malit O. Pioon Maggie A. Sawdy Laura Smale Raymond G. Cavalcante Karthik R. Padmanabhan Claudia Lalancette Bridgett vonHoldt Christopher D. Faulk Dana C. Dolinoy Kay E. Holekamp Wei Perng |
| spellingShingle |
Zachary M. Laubach Julia R. Greenberg Julie W. Turner Tracy M. Montgomery Malit O. Pioon Maggie A. Sawdy Laura Smale Raymond G. Cavalcante Karthik R. Padmanabhan Claudia Lalancette Bridgett vonHoldt Christopher D. Faulk Dana C. Dolinoy Kay E. Holekamp Wei Perng Early-life social experience affects offspring DNA methylation and later life stress phenotype Nature Communications |
| author_facet |
Zachary M. Laubach Julia R. Greenberg Julie W. Turner Tracy M. Montgomery Malit O. Pioon Maggie A. Sawdy Laura Smale Raymond G. Cavalcante Karthik R. Padmanabhan Claudia Lalancette Bridgett vonHoldt Christopher D. Faulk Dana C. Dolinoy Kay E. Holekamp Wei Perng |
| author_sort |
Zachary M. Laubach |
| title |
Early-life social experience affects offspring DNA methylation and later life stress phenotype |
| title_short |
Early-life social experience affects offspring DNA methylation and later life stress phenotype |
| title_full |
Early-life social experience affects offspring DNA methylation and later life stress phenotype |
| title_fullStr |
Early-life social experience affects offspring DNA methylation and later life stress phenotype |
| title_full_unstemmed |
Early-life social experience affects offspring DNA methylation and later life stress phenotype |
| title_sort |
early-life social experience affects offspring dna methylation and later life stress phenotype |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-07-01 |
| description |
Early social experience can alter epigenetic patterns and stress responses later in life. A study on wild spotted hyenas finds that maternal care and social connections after leaving the den influence DNA methylation and contribute to a developmentally plastic stress response. |
| url |
https://doi.org/10.1038/s41467-021-24583-x |
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