Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Abstract Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained...

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Bibliographic Details
Main Authors: Katsunori Katagiri, Kiyoto Shiga, Daisuke Saito, Shin‐ichi Oikawa, Aya Ikeda, Kodai Tsuchida, Jun Miyaguchi
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Clinical Case Reports
Subjects:
glucocorticoids
interstitial pneumonitis
lung metastasis
mucosal malignant melanoma
nivolumab
Online Access:https://doi.org/10.1002/ccr3.2349

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