Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Abstract Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained...

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Main Authors: Katsunori Katagiri, Kiyoto Shiga, Daisuke Saito, Shin‐ichi Oikawa, Aya Ikeda, Kodai Tsuchida, Jun Miyaguchi
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Clinical Case Reports
Subjects:
glucocorticoids
interstitial pneumonitis
lung metastasis
mucosal malignant melanoma
nivolumab
Online Access:https://doi.org/10.1002/ccr3.2349
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spelling doaj-268e9078312c4948b6faf833f982482b2020-11-24T21:11:28ZengWileyClinical Case Reports2050-09042019-09-01791709171310.1002/ccr3.2349Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanomaKatsunori Katagiri0Kiyoto Shiga1Daisuke Saito2Shin‐ichi Oikawa3Aya Ikeda4Kodai Tsuchida5Jun Miyaguchi6Department of Head and Neck Surgery Iwate Medical University Morioka JapanDepartment of Head and Neck Surgery Iwate Medical University Morioka JapanDepartment of Head and Neck Surgery Iwate Medical University Morioka JapanDepartment of Head and Neck Surgery Iwate Medical University Morioka JapanDepartment of Head and Neck Surgery Iwate Medical University Morioka JapanDepartment of Head and Neck Surgery Iwate Medical University Morioka JapanDepartment of Head and Neck Surgery Iwate Medical University Morioka JapanAbstract Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.https://doi.org/10.1002/ccr3.2349glucocorticoidsinterstitial pneumonitislung metastasismucosal malignant melanomanivolumab
collection DOAJ
language English
format Article
sources DOAJ
author Katsunori Katagiri
Kiyoto Shiga
Daisuke Saito
Shin‐ichi Oikawa
Aya Ikeda
Kodai Tsuchida
Jun Miyaguchi
spellingShingle Katsunori Katagiri
Kiyoto Shiga
Daisuke Saito
Shin‐ichi Oikawa
Aya Ikeda
Kodai Tsuchida
Jun Miyaguchi
Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
Clinical Case Reports
glucocorticoids
interstitial pneumonitis
lung metastasis
mucosal malignant melanoma
nivolumab
author_facet Katsunori Katagiri
Kiyoto Shiga
Daisuke Saito
Shin‐ichi Oikawa
Aya Ikeda
Kodai Tsuchida
Jun Miyaguchi
author_sort Katsunori Katagiri
title Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_short Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_full Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_fullStr Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_full_unstemmed Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_sort amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
publisher Wiley
series Clinical Case Reports
issn 2050-0904
publishDate 2019-09-01
description Abstract Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.
topic glucocorticoids
interstitial pneumonitis
lung metastasis
mucosal malignant melanoma
nivolumab
url https://doi.org/10.1002/ccr3.2349
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AT kiyotoshiga amplificationandattenuationoflungmetastasesdependingonglucocorticoiddosageimplicatinglongactingactivatedmemorycellsinducedbynivolumabagainstmalignantmelanoma
AT daisukesaito amplificationandattenuationoflungmetastasesdependingonglucocorticoiddosageimplicatinglongactingactivatedmemorycellsinducedbynivolumabagainstmalignantmelanoma
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