Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane

An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 mg/mL; IC50 (W2) = 0.29 mg/mL...

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Main Authors:	BOGDAN A. SOLAJA, WILBUR K. MILHOUS, GABRIELLA POCSFALVI, DEJAN OPSENICA
Format:	Article
Language:	English
Published:	Serbian Chemical Society 2002-07-01
Series:	Journal of the Serbian Chemical Society
Subjects:	tetraoxane malaria peroxide steroid intramolecular
Online Access:	http://www.shd.org.yu/HtDocs/SHD/Vol67/No7/V67-No7-01.pdf

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spelling	doaj-268cf79a5a0d4a8cba11815377c2d0812020-11-24T21:02:08ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51392002-07-01677465471Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane BOGDAN A. SOLAJAWILBUR K. MILHOUSGABRIELLA POCSFALVIDEJAN OPSENICAAn intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 mg/mL; IC50 (W2) = 0.29 mg/mL). http://www.shd.org.yu/HtDocs/SHD/Vol67/No7/V67-No7-01.pdftetraoxanemalariaperoxidesteroidintramolecular
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	BOGDAN A. SOLAJA WILBUR K. MILHOUS GABRIELLA POCSFALVI DEJAN OPSENICA
spellingShingle	BOGDAN A. SOLAJA WILBUR K. MILHOUS GABRIELLA POCSFALVI DEJAN OPSENICA Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane Journal of the Serbian Chemical Society tetraoxane malaria peroxide steroid intramolecular
author_facet	BOGDAN A. SOLAJA WILBUR K. MILHOUS GABRIELLA POCSFALVI DEJAN OPSENICA
author_sort	BOGDAN A. SOLAJA
title	Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
title_short	Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
title_full	Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
title_fullStr	Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
title_full_unstemmed	Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
title_sort	antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
publisher	Serbian Chemical Society
series	Journal of the Serbian Chemical Society
issn	0352-5139
publishDate	2002-07-01
description	An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 mg/mL; IC50 (W2) = 0.29 mg/mL).
topic	tetraoxane malaria peroxide steroid intramolecular
url	http://www.shd.org.yu/HtDocs/SHD/Vol67/No7/V67-No7-01.pdf
work_keys_str_mv	AT bogdanasolaja antimalarialperoxidesthefirstintramolecular1245tetraoxane AT wilburkmilhous antimalarialperoxidesthefirstintramolecular1245tetraoxane AT gabriellapocsfalvi antimalarialperoxidesthefirstintramolecular1245tetraoxane AT dejanopsenica antimalarialperoxidesthefirstintramolecular1245tetraoxane
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Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane

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